Kuliah dr Ni Nengah Dwi Fatmawati, SpMK

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Sumber bahan kuliah dari CLSI 2017

Baronic acid test
Combination meropenem
(EUCAST,2017)

MRSA
Deteksi dengan MIC, disk infusion, broth microdilution

VRSA dan Enterococcus spp.
MIC, deteksi dengan Vancomycin

MRSA kalau resisten vancomycin dilakukan pengulangan resistensi antibiotik

In vitro vs in vivo
Mekanisme resistensi 

Infected vs colonized 

- Infection prevention and control

Isolation precautions standard and contact precautions

Antibiotic resistance mechanisms detection
MDR dari lingkungan gimana caranya deteksinya?

MDRO ??

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A. MALDI TOF Several commercial test pNA-FISH Cartridges verigene, geneexpert, filmarray bcid Artikel housin 2016,lab chip Ultrafast, sensitive, and large volume on chip real time PCR for the molecular Antibiotic susceptibility testing in less than PNAS 2013, 30 menit Whole genome sequencing as a typing method DNA molecule of bacteria Large DNA molecule One big bacterial genome Epidemiological characterization of nosocomial outbreak of ESBL ST 3 Zhou, Sci Rep 2016 Intestinal microbiota Microbiome = collective gene Methods to study microbiome Gut 2008 Composition and luminal concentrations of dominant Falony et al, science 2016 Microbiome and associated with disease Dysbiosis = dysrefugulated microbiota such as IBD, diabetes , metabolic syndrome, atherosclerosis, parkinson, cirrhosis, carcinoma etc Glance into the future of microbiology
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